This article comparing Drupal to Django is pretty old but I just noticed it. There is a nice summary in the conclusion:
Drupal represents a middle ground between framework and CMS that we’ve chosen not to take. Drupal is far more capable than a CMS like WordPress, but also much less flexible than a pure framework. But more importantly, the facts that Drupal isn’t object-oriented, isn’t MVC/MTV, doesn’t have an ORM, and is generally less flexible than a pure framework, not to mention our preference for working in Python over PHP, all contribute to our decision not to use it.
I reached a similar conclusion on a recent project.